Joshua E Allen Selected Research

TIC10 compound

3/2024	ACTION: A randomized phase 3 study of ONC201 (dordaviprone) in patients with newly diagnosed H3 K27M-mutant diffuse glioma.
2/2024	Safety and pharmacokinetics of ONC201 (dordaviprone) administered two consecutive days per week in pediatric patients with H3 K27M-mutant glioma.
2/2024	Selective DRD2 Antagonist and ClpP Agonist ONC201 in a Recurrent Non-midline H3 K27M-mutant Glioma Cohort.
2/2024	ONC201 (Dordaviprone) in Recurrent H3 K27M-Mutant Diffuse Midline Glioma.
1/2024	The oncolytic adenovirus Delta-24-RGD in combination with ONC201 induces a potent antitumor response in pediatric high-grade and diffuse midline glioma models.
11/2023	Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways.
1/2022	Anti-Tumor and Anti-Invasive Effects of ONC201 on Ovarian Cancer Cells and a Transgenic Mouse Model of Serous Ovarian Cancer.
1/2022	Phase II Study of ONC201 in Neuroendocrine Tumors including Pheochromocytoma-Paraganglioma and Desmoplastic Small Round Cell Tumor.
1/2022	ONC206 has anti-tumorigenic effects in human ovarian cancer cells and in a transgenic mouse model of high-grade serous ovarian cancer.
1/2022	Serial H3K27M cell-free tumor DNA (cf-tDNA) tracking predicts ONC201 treatment response and progression in diffuse midline glioma.

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Joshua E Allen Research Topics

Disease

63	Neoplasms (Cancer) 01/2024 - 11/2009
15	Glioma (Gliomas) 03/2024 - 01/2019
7	Hematologic Neoplasms (Hematological Malignancy) 02/2021 - 02/2016
7	Glioblastoma (Glioblastoma Multiforme) 01/2021 - 01/2017
7	Colorectal Neoplasms (Colorectal Cancer) 01/2017 - 10/2010
6	Prostatic Neoplasms (Prostate Cancer) 01/2022 - 04/2014
5	Endometrial Neoplasms (Endometrial Cancer) 12/2023 - 01/2020
4	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2024 - 02/2016
4	Colonic Neoplasms (Colon Cancer) 02/2013 - 08/2011
3	Brain Neoplasms (Brain Tumor) 01/2021 - 05/2014
3	Mantle-Cell Lymphoma (Lymphoma, Mantle Cell) 12/2020 - 02/2016
3	Multiple Myeloma 01/2018 - 11/2012
2	Neuroendocrine Tumors (Neuroendocrine Tumor) 01/2022 - 01/2022
2	Ovarian Neoplasms (Ovarian Cancer) 01/2022 - 01/2022
2	Diffuse Intrinsic Pontine Glioma 01/2022 - 04/2019
2	Non-Hodgkin Lymphoma (Lymphosarcoma) 01/2018 - 08/2015
2	Cutaneous T-Cell Lymphoma (Lymphoma, T Cell, Cutaneous) 01/2018 - 09/2017
2	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2018 - 01/2013
2	Melanoma (Melanoma, Malignant) 10/2017 - 01/2013
2	Hepatocellular Carcinoma (Hepatoma) 04/2015 - 08/2011
2	Circulating Neoplastic Cells 01/2015 - 01/2015
2	Neoplasm Metastasis (Metastasis) 05/2014 - 10/2010
2	Hypoxia (Hypoxemia) 04/2014 - 08/2011
2	Giardiasis 08/2011 - 08/2011
1	Vomiting 01/2022
1	Dizziness (Lightheadedness) 01/2022
1	Headache (Headaches) 01/2022
1	Body Weight (Weight, Body) 01/2022
1	Paraganglioma (Paragangliomas) 01/2022
1	Nausea 01/2022
1	Adenocarcinoma 01/2022
1	Pheochromocytoma 01/2022
1	Desmoplastic Small Round Cell Tumor 01/2022
1	Schizophrenia (Dementia Praecox) 10/2021
1	Obesity 02/2021
1	Medulloblastoma 01/2021
1	Starvation 01/2021
1	medullary Thyroid cancer 01/2021
1	Thyroid Neoplasms (Thyroid Cancer) 01/2021
1	Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse) 01/2018
1	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 01/2018
1	Leukemia 01/2018
1	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 01/2018
1	Burkitt Lymphoma (Burkitt's Lymphoma) 01/2018
1	Hodgkin Disease (Hodgkin's Disease) 01/2018
1	Sclerosis 01/2018
1	Anaplastic Large-Cell Lymphoma (Ki 1 Lymphoma) 01/2018

Drug/Important Bio-Agent (IBA)

44	TIC10 compoundIBA 03/2024 - 12/2014
13	Dopamine Receptors (Dopamine Receptor)IBA 12/2023 - 01/2019
9	Proteins (Proteins, Gene)FDA Link 01/2021 - 08/2011
7	Biomarkers (Surrogate Marker)IBA 01/2018 - 01/2013
6	ONC206IBA 12/2023 - 10/2017
4	Peptide Hydrolases (Proteases)FDA Link 12/2023 - 01/2022
4	LigandsIBA 01/2022 - 01/2013
4	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 12/2019 - 10/2017
4	Sorafenib (BAY 43-9006)FDA Link 04/2015 - 08/2011
4	Fluorouracil (Carac)FDA LinkGeneric 04/2015 - 08/2011
3	dipinacoline glutamateIBA 02/2024 - 10/2019
3	Histones (Histone)IBA 02/2024 - 04/2019
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2022 - 01/2013
3	ONC212IBA 12/2019 - 10/2017
3	Phosphotransferases (Kinase)IBA 02/2016 - 08/2011
3	Antineoplastic Agents (Antineoplastics)IBA 04/2015 - 01/2013
3	Death Domain ReceptorsIBA 01/2013 - 10/2012
2	Monoclonal AntibodiesIBA 12/2023 - 01/2015
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2022 - 01/2021
2	RNA (Ribonucleic Acid)IBA 01/2022 - 01/2017
2	Messenger RNA (mRNA)IBA 02/2021 - 01/2021
2	TNF-Related Apoptosis-Inducing Ligand ReceptorsIBA 12/2020 - 11/2020
2	Bevacizumab (Avastin)FDA Link 04/2019 - 10/2017
2	Dexamethasone (Maxidex)FDA LinkGeneric 04/2019 - 01/2018
2	Bortezomib (Velcade)FDA Link 01/2018 - 02/2016
2	DNA (Deoxyribonucleic Acid)IBA 08/2015 - 01/2015
2	Quinacrine (Mepacrine)IBA 08/2011 - 08/2011
1	Adrenal Cortex Hormones (Corticosteroids)IBA 02/2024
1	Oxidoreductases (Dehydrogenase)IBA 01/2024
1	olaparibIBA 12/2023
1	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 12/2023
1	Poly(ADP-ribose) Polymerase InhibitorsIBA 12/2023
1	HydrogelsIBA 01/2022
1	Androgen Receptors (Androgen Receptor)IBA 01/2022
1	Dopamine (Intropin)FDA LinkGeneric 01/2022
1	N 30IBA 01/2022
1	Alanine Transaminase (SGPT)IBA 01/2022
1	Circulating Tumor DNAIBA 01/2022
1	LipidsIBA 02/2021
1	ErbB Receptors (EGF Receptor)IBA 01/2021
1	Deoxyglucose (2 Deoxy D glucose)IBA 01/2021
1	Glucose (Dextrose)FDA LinkGeneric 01/2021
1	Haloperidol (Haldol)FDA LinkGeneric 01/2021
1	Proto-Oncogene Proteins c-retIBA 01/2021
1	Drug CombinationsIBA 11/2018
1	Cytarabine (Cytosar-U)FDA LinkGeneric 01/2018

Therapy/Procedure

24	Therapeutics 03/2024 - 10/2010
10	Drug Therapy (Chemotherapy) 10/2017 - 08/2011
4	Radiotherapy 03/2024 - 04/2019
2	Fat-Restricted Diet (Diet, Fat Restricted) 01/2022 - 02/2021
1	Investigational Therapies (Experimental Therapy) 01/2022
1	Castration 01/2022
1	Oral Administration 01/2019